Co-crystals are drawing much attention nowadays as they may exhibit better performances, concerning stability, solubility and processability, compared to single-component polymorphs. As a definition, co-crystals are crystalline materials composed of two or more different molecules, typically active pharmaceutical ingredient (API) and co-crystal formers (‘coformers’), in the same crystal lattice. A diagram of classification of solid forms are shown in Figure 1. Co-crystals are different from salts in that molecules are combined with supramolecular interactions, instead of ionic interactio...
发布时间:
2020
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