Solid Dosage Form Development Platform
Topical Formulation
Development Platform
Oral Film Formulation Development Platform
Commercial Manufacturing
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Advantages of Topical Formulation
■ Non-invasive administration prevents gastrointestinal irritation and avoids first-pass liver metabolism, minimizing systemic side effects and improving patient safety and efficacy.
■ Utilizing the skin as a drug reservoir provides sustained release, maintaining steady blood concentrations to prevent peak-and-trough effects. This allows for predictable and extended duration of action, reducing dosing frequency and enhancing medication safety and compliance.
■ Suitable for patients sensitive to pain, with impaired consciousness, or difficulty swallowing, it allows for self-administration and interruption of dosing as needed, thereby improving patient adherence.
By inhibiting amorphous re-crystallization or polymorphic transformation in products, flexible control over the molecular and solid-state ratios of active pharmaceutical ingredients can be achieved. This ensures rational pharmacokinetic behavior for topical formulations, guaranteeing drug safety, efficacy, and quality control.
Self-emulsifying/nano-delivery systems
Utilizing the technological advantages of self-emulsifying/nano-delivery systems enhances drug penetration, adjusts drug delivery depth into the skin, aiming for local accumulation or systemic circulation. Nanotechnology not only improves drug dissolution and permeation but also prolongs drug release from carriers, effectively reducing dosing frequency and minimizing drug side effects.
Based on years of accumulated experience, our company has developed a comprehensive quality assessment method for semi-solid formulations based on rheological data. Through thorough rheological evaluation, we assess various semi-solid formulations such as uniformity, droplet dispersion, suspension stability, and compare them with reference formulations, ensuring robust characterization of formulation rheological properties and product stability.
Evaluation of in vitro release and in vitro transdermal permeation tests.
Transdermal drug delivery systems allow drugs to be absorbed through the skin, achieving effective blood drug concentrations locally or systemically for disease prevention or treatment. Compared to traditional delivery methods like oral administration or injections, transdermal systems offer several advantages.
Due to the physiological environment, transdermal systems have strict requirements regarding the molecular and solid-state proportions of drugs in formulations. Only drugs in their molecular form can permeate through the stratum corneum for skin penetration. However, with the development of new chemical entities, the proportion of poorly soluble drugs has increased to as high as 90%. Addressing drug solubility has thus become a key focus in formulation development research.
PXRD、Raman Spectroscopy、DSC、TGA、DVS、Particle Size Analyze、Parallel Crystallizer、 Polarized Light Microscope、Spray Dryer、 Fully Automated Grinder、High Performance Liquid Chromatography、Tablet Press、Film Coater
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The company has developed solid-state improved
formulations and obtained patents for over 50 types of drugs.
Improving drug absorption through solid-state technology is the foundation of all innovative technologies at Xinyang Weikang.
Headquarters Address: Building A3, Guanming Technology Park, No. 3009 Guangming Avenue, Fenghuang Community, Fenghuang Street, Guangming District, Shenzhen
Production Base Address: Weiguang Life Science Park, Guangming District, Shenzhen
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