Drug solid-state screening
Rapid and precise deciphering of complex formulations
In-depth analysis of
solid-state properties
Development and Industrialization of Solid State
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第一行主标题 请输入要描述的内容进行内容补充请输入 - Salt and Solid State Screening 第一行主标题 请输入要描述的内容进行内容补充请输入 - Assessment of Drug Efficacy 第一行主标题 请输入要描述的内容进行内容补充请输入 - Evaluation of Eutectic Systems 第一行主标题 请输入要描述的内容进行内容补充请输入 - Development of Co-crystal |
Development of Amorphous form Reasonable design of amorphous solid dispersion Stable, efficient, and industrializable Amorphous form is the most significant enhancement in efficacy among metastable crystal forms. Amorphous drugs exhibit high surface free energy and are prone to crystallization during storage and dissolution, potentially losing advantages over crystalline formulations. Our company’s latest generation solid dispersion technology achieves nearly infinite stability for amorphous drug systems, driving commercialization of amorphous drugs. Leveraging extensive experience in amorphous preparation and analysis, we offer comprehensive services tailored to your amorphous-related projects. To stabilize the amorphous state of drugs and prevent crystallization in both solid-state and aqueous phases, excipients are typically introduced into multi-component amorphous systems (amorphous solid dispersions). This approach enhances the stability of amorphous drugs while improving the functionality and processability of their formulations. It can address issues such as viscosity, powder flowability, and hygroscopicity. Figure: Preparation target of amorphous solid dispersion Properties of amorphous products Amorphous materials exhibit unique characteristics due to their disordered state compared to crystalline forms: ■ Amorphous forms typically demonstrate significantly higher apparent solubility than crystalline forms. When solutes in supersaturated solutions begin to crystallize and reach dynamic equilibrium, the solubility can increase dramatically (often more than 10-fold). Therefore, utilizing amorphous forms can significantly enhance the bioavailability of drugs. ■ Due to the structural disorder of amorphous materials, their mechanical properties can differ noticeably from their crystalline counterparts. Experimental findings indicate that tablets formed from powders of amorphous drugs can be more brittle under certain conditions compared to tablets made from crystalline drugs.Amorphous materials also exhibit higher hygroscopicity, absorbing more moisture in typical environmental conditions than crystalline forms. ■ Amorphous forms have very strong water absorption properties, and in ordinary environments, amorphous forms absorb more water than crystalline forms. Typically, marketed amorphous solid dispersions refer to single-phase dispersions where the drug is amorphously dispersed in a solid carrier. Amorphous drugs in such systems exhibit higher apparent solubility compared to crystalline drugs. Additionally, the solid carrier enhances drug dispersion, increasing the drug's dissolution surface area and improving the dissolution rate of poorly soluble drugs, thereby further enhancing their oral bioavailability. Advantages of amorphous drugs: High solubility, fast dissolution rate, and high bioavailability can improve the water solubility and bioavailability of poorly soluble drugs. |
Solid State Research
Improving drug absorption through solid-state technology is the foundation of all innovative technologies at Xinyang Weikang.
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Innovative Improved Drugs
Our company strategically focuses on developing high-end formulations, successfully completing numerous advanced oral film formulations, and establishing a systematic approach to formulation development.
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CDMO
We are the only integrated domestic platform specializing in crystalline formulation production, strictly adhering to GMP standards. We specialize in scaling up research and commercial production of various dosage forms including oral films, topical formulations, and solid formulations.
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Nycrist Phamatech Co.,Ltd
Tel：19129598229
19129598368（Mr.Lee）
19926561149（Mrs.Chen）
19926414326（Mr.Liu）
Headquarters Address: Building A3, Guanming Technology Park, No. 3009 Guangming Avenue, Fenghuang Community, Fenghuang Street, Guangming District, Shenzhen
Production Base Address: Weiguang Life Science Park, Guangming District, Shenzhen
Business Team
Business Contact
Wechat
Recruitment
HR：0755-23411222
19145082504（Mr.lee）
Address
Email：BD@nycrist.cn
