Polymorphy screening
Rapid and precise deciphering of complex formulations
In-depth analysis of
solid-state properties
Development and Industrialization of Solid State
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第一行主标题 请输入要描述的内容进行内容补充请输入 - Establishing of quality standards for Polymorphy content limits 第一行主标题 请输入要描述的内容进行内容补充请输入 - Development of Methods for Controlling Particle Size and Crystal Habit 第一行主标题 请输入要描述的内容进行内容补充请输入 - Study and Prediction of Solid-State Stability |
Single crystal growth and structural identification Single crystal structure analysis is a crucial method for determining the composition and crystal structure of compounds, and it is the most comprehensive and commonly used research approach available. It enables enterprises to gain a competitive edge in new drug applications, quality control, patent protection, and property analysis. Single crystal analysis provides essential information such as crystallographic parameters, molecular symmetry (crystal system, space group), molecular bonding interactions (hydrogen bonds, salt bridges, coordination bonds), molecular conformations, absolute configurations, and more, offering microscopic structural insights into crystalline substances at the molecular and atomic levels. In pharmaceutical applications, single crystals can be grown and their structures analyzed for drugs with polymorphic forms, facilitating smooth drug application processes. Furthermore, single crystal X-ray diffraction can confirm different crystal structures, thereby elucidating differences observed in physical properties and transformations between crystal forms, providing valuable insights. Single crystal growth methods:
To conduct single crystal analysis, it is essential first to grow single crystals suitable for experimental measurements. Common methods for growing single crystals include (1) slow evaporation, (2) cooling crystallization, (3) vapor diffusion, (4) solvent diffusion, and (5) melt crystallization. Diagram illustrating crystallization methods Once single crystals suitable for experimental measurements are obtained, single crystal X-ray diffraction can be conducted to determine their structure. The commonly used software for single crystal diffraction analysis is typically shelx, which includes submodules such as shelxs (structure solution), shelxd (structure determination), shelxt (structure refinement), shelxl (structure finalization), and shelxh (large structure refinement). The diffraction intensity of single crystal diffraction spots, along with their corresponding hkl indices and unit cell parameters, constitutes the basic data for crystal structure analysis. Through crystal structure analysis, crystal diagrams can be generated, and crystal databases can be searched to effectively utilize and extract crystal structure information. Accurately determining the molecular structure of APIs in the early stages of drug development can reduce unnecessary experiments, thereby saving time and costs. New Yangweikang aims to contribute to enhancing the quality of life for patients through pharmaceutical research and development. Additionally, the company continually updates and introduces state-of-the-art equipment to provide our clients with more efficient and accurate solutions. If you have any requirements related to solid-state drugs, please feel free to contact us. |
Solid State Research
Improving drug absorption through solid-state technology is the foundation of all innovative technologies at Xinyang Weikang.
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Innovative Improved Drugs
Our company strategically focuses on developing high-end formulations, successfully completing numerous advanced oral film formulations, and establishing a systematic approach to formulation development.
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CDMO
We are the only integrated domestic platform specializing in crystalline formulation production, strictly adhering to GMP standards. We specialize in scaling up research and commercial production of various dosage forms including oral films, topical formulations, and solid formulations.
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Nycrist Phamatech Co.,Ltd
Tel：19129598229
19129598368（Mr.Lee）
19926561149（Mrs.Chen）
19926414326（Mr.Liu）
Headquarters Address: Building A3, Guanming Technology Park, No. 3009 Guangming Avenue, Fenghuang Community, Fenghuang Street, Guangming District, Shenzhen
Production Base Address: Weiguang Life Science Park, Guangming District, Shenzhen
Business Team
Business Contact
Wechat
Recruitment
HR：0755-23411222
19145082504（Mr.lee）
Address
Email：BD@nycrist.cn
